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KMID : 0361020200630120579
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Korean Journal of Otolaryngology - Head and Neck Surgery
2020 Volume.63 No. 12 p.579 ~ p.585
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Endotype of Eosinophilic Nasal Polyposis According to the Presence of Atopy
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Kim Do-Hyun
Kim Boo-Young
Lee Il-Hwan
Kim Sung-Won
Kim Soo-Whan
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Abstract
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Background and Objectives : We evaluated differences in the pathophysiology of atopicand non-atopic eosinophilic nasal polyps and investigated their distinct inflammatory profiles.
Subjects and Method : A total of 36 patients were recruited: 10 controls (Group C), 14 withchronic rhinosinusitis with eosinophilic nasal polyps with atopy (Group A), and 12 without atopy(Group NA).
Results : Serum eosinophil counts, total immunoglobulin E, eosinophil cationic protein levels,and tissue eosinophil counts were elevated in Groups A and NA vs. Group C. Real-timepolymerase chain reaction results showed increased GATA-3, interleukin (IL)-4, IL-33 levels,but decreased levels of retinoic acid-related orphan receptor gamma t, IL-17 in Groups A andNA. Related to the regulatory T (T-reg) cell response, forkhead box P3 (Foxp3+) (A: p<0.001,NA: p<0.001) and IL-10 (A: p<0.001, NA: p<0.001) levels were elevated and transforminggrowth factor-β levels (A: p<0.001, NA: p<0.001) were decreased in Group A and Group NA incomparison to those in Group C. The Foxp3+ (p=0.001) and IL-10 (p<0.001) were significantlyhigher in Group A than in Group NA.
Conclusion : T-reg cells and IL-10 may be major factors differentiating the pathophysiology ofatopic and non-atopic eosinophilic nasal polyps, and the T helper (Th) 2/Th17/T-reg imbalancemight be important in the development of eosinophilic nasal polyposis.
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KEYWORD
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Eosinophilia, Hypersensitivity, immediate, Nasal polyps
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